Query String: MITOXANTRONE
BDBM50427751 MITOXANTRONE DIHYDROCHLORIDE Mitoxantrone Dihcl
CHEMBL58 MITOXANTRONE BDBM50003674
1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis(oxidanyl)anthracene-9,10-dione;hydrochloride 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;hydrochloride MITOXANTRONE BDBM67690 DHAD MITOXANTRONE DIHYDROCHLORIDE cid_4212 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-9,10-anthraquinone;hydrochloride MLS001333711 cid_5458171 SMR000058480
- Morrow, CS; Peklak-Scott, C; Bishwokarma, B; Kute, TE; Smitherman, PK; Townsend, AJ Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol 69: 1499-505 (2006)
- Wan, X; Zhang, W; Li, L; Xie, Y; Li, W; Huang, N A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J Med Chem 56: 2619-29 (2013)
- ChEMBL_2171577 (CHEMBL5056711) Inhibition of ABCG2 in mitoxantrone-selected ABCG2-overexpressing human NCI-H460/MX20 cells assessed as increase in intracellular mitoxantrone accumulation incubated for 1 hr in presence of mitoxantrone by flow cytometry
- ChEMBL_1286801 (CHEMBL3112046) Inhibition of ABCG2-mediated mitoxantrone efflux in mitoxantrone-selected human H460 cells after 30 mins by flow cytometric analysis
- ChEMBL_2215555 (CHEMBL5128687) Inhibition of human ABCG2 expressed in human SAOS-2 cells mediated mitoxantrone efflux using mitoxantrone as substrate by flow cytometry
- ChEMBL_2215565 (CHEMBL5128697) Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level preincubated with mitoxantrone followed by compound addition and measured upto 60 mins by FACSflow cytometry analysis
- ChEMBL_2215561 (CHEMBL5128693) Inhibition of ABCG2 (unknown origin) expressed in human MCF7/MX cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level preincubated with mitoxantrone followed by compound addition and measured upto 90 mins by FACSflow cytometry analysis
- ChEMBL_2215586 (CHEMBL5128718) Inhibition of ABCG2 (unknown origin) expressed in human S1M180 cells mediated [3H]-mitoxantrone efflux assessed as intracellular [3H]-mitoxantrone level by flow cytometry
- ChEBML_1696291 Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC50 at 10 uM preincubated for 2 hrs followed by mitoxantrone addition measured after 72 hrs by MTT assay (Rvb = 6.161 +/- 0.172 microM)
- ChEMBL_1696291 (CHEMBL4047181) Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC50 at 10 uM preincubated for 2 hrs followed by mitoxantrone addition measured after 72 hrs by MTT assay (Rvb = 6.161 +/- 0.172 microM)
- ChEMBL_1696305 (CHEMBL4047195) Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC50 at 3 uM preincubated for 2 hrs followed by mitoxantrone addition measured after 72 hrs by MTT assay (Rvb = 6.161 +/- 0.172 microM)
- ChEMBL_1696306 (CHEMBL4047196) Inhibition of ABCG2 in human H460/MX20 cells assessed as potentiation of mitoxantrone induced antiproliferative activity by measuring mitoxantrone IC50 at 1 uM preincubated for 2 hrs followed by mitoxantrone addition measured after 72 hrs by MTT assay (Rvb = 6.161 +/- 0.172 microM)
- ChEMBL_1617829 (CHEMBL3859898) Inhibition of BCRP in human MCF7/Topo cells assessed as mitoxantrone accumulation preincubated for 10 mins followed by mitoxantrone addition measured after 30 mins by fluorescence assay
- ChEMBL_835942 (CHEMBL2077080) TP_TRANSPORTER: drug resistance(Mitoxantrone) in BCRP-expressing K562 cells
- ChEMBL_2171578 (CHEMBL5056712) Inhibition of ABCG2 in becatecarin-selected ABCG2-overexpressing human A549/Bec150 cells assessed as increase in intracellular mitoxantrone accumulation incubated for 1 hr in presence of mitoxantrone by flow cytometry
- ChEMBL_2215571 (CHEMBL5128703) Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level and measured after 30 mins by FACSflow cytometry analysis
- ChEMBL_2215570 (CHEMBL5128702) Inhibition of ABCG2 (unknown origin) expressed in human MCF7/MX cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level and measured after 30 mins by FACSflow cytometry analysis
- ChEMBL_2215572 (CHEMBL5128704) Inhibition of ABCG2 (unknown origin) expressed in human MCF7-VP cells mediated mitoxantrone efflux assessed as intracellular mitoxantrone level and measured after 45 mins by flow cytometry analysis
- ChEMBL_811063 (CHEMBL2014643) Inhibition of ABCG2-mediated mitoxantrone efflux in HEK293 cells by flow cytometry
- ChEMBL_836310 (CHEMBL2076474) TP_TRANSPORTER: increase in mitoxantrone intracellular accumulation in BCRP-expressing HEK cells
- ChEMBL_836761 (CHEMBL2075183) TP_TRANSPORTER: inhibition of mitoxantrone efflux in BCRP-expressing MCF7-MX cells
- ChEMBL_2083517 (CHEMBL4739308) Reversal of BCRP-mediated multidrug resistance in human KBV cells assessed as mitoxantrone IC50 at 5 uM after 72 hrs in presence of mitoxantrone by MTT assay (Rvb = 1186.50 +/- 29.24 nM)
- ChEMBL_2083518 (CHEMBL4739309) Reversal of BCRP-mediated multidrug resistance in human KBV cells assessed as mitoxantrone IC50 at 10 uM after 72 hrs in presence of mitoxantrone by MTT assay (Rvb = 1186.50 +/- 29.24 nM)
- ChEMBL_2101062 (CHEMBL4809458) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 40000 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101063 (CHEMBL4809459) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 10000 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101064 (CHEMBL4809460) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 5000 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101065 (CHEMBL4809461) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 1250 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101066 (CHEMBL4809462) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 500 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101067 (CHEMBL4809463) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 250 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101068 (CHEMBL4809464) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 75 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101069 (CHEMBL4809465) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 37.5 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101070 (CHEMBL4809466) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 12.5 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_2101071 (CHEMBL4809467) Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of mitoxantrone-induced cytotoxicity at 3.125 nM by measuring mitoxantrone IC50 after 48 hrs by MTT assay
- ChEMBL_1553397 (CHEMBL3768161) Inhibition of human ABCG2 expressed in HEK293 cells by mitoxantrone flow cytometric analysis
- ChEMBL_428971 (CHEMBL919518) Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation
- ChEMBL_512916 (CHEMBL974473) Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay
- ChEMBL_442566 (CHEMBL892735) Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry
- ChEMBL_1995609 (CHEMBL4629504) Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 50.66 +/- 6.88 nM)
- ChEMBL_1995610 (CHEMBL4629505) Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 50.66 +/- 6.88 nM)
- ChEMBL_1995611 (CHEMBL4629506) Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 50.66 +/- 6.88 nM)
- ChEMBL_1995613 (CHEMBL4629508) Reversal of human ABCG2-mediated multidrug resistance in HEK293/R482 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 50.66 +/- 6.88 nM)
- ChEMBL_465978 (CHEMBL931162) Inhibition of human BCRP pump mediated [3H]mitoxantrone transport in human Caco-2 cells
- ChEMBL_1995549 (CHEMBL4629444) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 1160.60 +/- 365.72 nM)
- ChEMBL_1995550 (CHEMBL4629445) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 1160.60 +/- 365.72 nM)
- ChEMBL_1995551 (CHEMBL4629446) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 1160.60 +/- 365.72 nM)
- ChEMBL_1995552 (CHEMBL4629447) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human H460-MX20 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 1160.60 +/- 365.72 nM)
- ChEMBL_1995581 (CHEMBL4629476) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
- ChEMBL_1995582 (CHEMBL4629477) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
- ChEMBL_1995583 (CHEMBL4629478) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
- ChEMBL_1995584 (CHEMBL4629479) Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
- ChEMBL_518478 (CHEMBL938929) Inhibition of ABCG2 overexpressed in human MCF7/Topo cells by flow cytometric-based mitoxantrone efflux assay
- ChEMBL_2244552 (CHEMBL5158762) Inhibition of human ABCG2 in human R5 cells assessed as inhibition of mitoxantrone efflux measured by flow cytometric analysis
- ChEMBL_512911 (CHEMBL974468) Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay using linear regression analysis
- ChEMBL_826625 (CHEMBL2050879) Inhibition of ABCG2-mediated mitoxantrone efflux expressed in HEK293 cells after 48 hrs by flow cytometric analysis
- ChEMBL_2053433 (CHEMBL4708434) Inhibition of ABCG2 (unknown origin) in HEK293 cells assessed as maximal inhibition of mitoxantrone efflux by fluorescence based flow cytometry
- ChEBML_1623937 Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux after 30 mins by flow cytometric analysis
- ChEMBL_1286800 (CHEMBL3112045) Inhibition of ABCG2 (unknown origin)-mediated mitoxantrone efflux expressed in HEK293 cells after 30 mins by flow cytometric analysis
- ChEMBL_1437665 (CHEMBL3381155) Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux after 30 mins by FACS method
- ChEMBL_512910 (CHEMBL974467) Inhibition of ABCG2 in human mitoxantrone-resistant MCF7 cells by Hoechst 33342 assay using one phase exponential association analysis
- ChEMBL_1765357 (CHEMBL4200604) Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux measured after 30 mins by fluorescence assay
- ChEMBL_1907421 (CHEMBL4409779) Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as increase in mitoxantrone accumulation incubated for 30 mins by flow cytometric method
- ChEMBL_1338452 (CHEMBL3240718) Inhibition of ABCG2 (unknown origin) transfected in HEK293 cells assessed as inhibition of mitoxantrone efflux after 30 mins by flow cytometry relative to control
- ChEMBL_1828960 (CHEMBL4328834) Inhibition of GFP-fused human ABCG2 expressed in MDCK2 cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 72 hrs by MTT assay
- ChEMBL_2110747 (CHEMBL4819597) Inhibition of human ABCG2 transfected in human HEK293 cells assessed as inhibition of mitoxantrone efflux measured after 30 mins by FACS Calibur cytometric analysis
- ChEMBL_2119416 (CHEMBL4828482) Inhibition of BCRP (unknown origin) expressed in human HEK293/R2 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assay
- ChEMBL_2119417 (CHEMBL4828483) Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assay
- ChEMBL_2119418 (CHEMBL4828484) Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assay
- ChEMBL_1717972 (CHEMBL4132972) Inhibition of human GFP-fused ABCG2 expressed in MDCK2 cells assessed as potentiation of mitoxantrone-induced cell growth inhibition after 72 hrs by MTT assay
- ChEMBL_1822781 (CHEMBL4322545) Inhibition of BCRP (unknown origin) expressed in human HEK293/R2 cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 5 days by MTS/PMS assay
- ChEMBL_1822782 (CHEMBL4322546) Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 5 days by MTS/PMS assay
- ChEMBL_1822783 (CHEMBL4322547) Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as potentiation of mitoxantrone-induced cytotoxicity after 5 days by MTS/PMS assay
- ChEMBL_1665911 (CHEMBL4015707) Inhibition of human GFP-fused ABCG2 expressed in MDCK2 cells assessed as potentiation of mitoxantrone induced cytotoxicity by measuring cell viability after 72 hrs by MTT assay
- ChEMBL_2110746 (CHEMBL4819596) Mixed inhibition of human ABCG2 transfected in human HEK293 cells assessed as Ki1 for inhibition of mitoxantrone efflux measured after 30 mins by FACS Calibur cytometric analysis
- ChEMBL_2110752 (CHEMBL4819602) Uncompetitive inhibition of human ABCG2 transfected in human HEK293 cells assessed as Ki2 for inhibition of mitoxantrone efflux measured after 30 mins by FACS Calibur cytometric analysis
- ChEMBL_2110758 (CHEMBL4819608) Mixed inhibition of human ABCG2 transfected in human HEK293 cells assessed as Ki2 for inhibition of mitoxantrone efflux measured after 30 mins by FACS Calibur cytometric analysis
- ChEMBL_2215568 (CHEMBL5128700) Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells assessed as reversal of BCRP-mediated mitoxantrone resistance and measured after 90 mins by FACSflow cytometry analysis
- ChEMBL_1338470 (CHEMBL3240932) Inhibition of ABCG2 (unknown origin) transfected in HEK293 cells assessed as inhibition of mitoxantrone efflux at 5 uM after 30 mins in presence of 0.02 uM Ko143 by flow cytometry
- ChEMBL_2110751 (CHEMBL4819601) Non-competitive inhibition of human ABCG2 transfected in human HEK293 cells assessed as Ki2 for inhibition of mitoxantrone efflux measured after 30 mins by FACS Calibur cytometric analysis
- ChEMBL_1338469 (CHEMBL3240931) Inhibition of ABCG2 (unknown origin) transfected in HEK293 cells assessed as inhibition of mitoxantrone efflux at 5 uM after 30 mins in presence of 0.1 uM chromone 1 by flow cytometry
- ChEMBL_1437089 (CHEMBL3381103) Modulation of BCRP1 mediated drug efflux in mitoxantrone-resistant human MES-SA cells assessed as accumulation of hoechst 33342 incubated for 15 mins prior to rhodamine-123 addition measured after 90 mins by fluorescence analysis
- ChEMBL_1338471 (CHEMBL3240933) Inhibition of ABCG2 (unknown origin) transfected in HEK293 cells assessed as inhibition of mitoxantrone efflux at 5 uM after 30 mins in presence of 0.1 uM (2E,2'E)-1,1'-(1,4-Phenylene)bis(3-(2,6-dimethoxyphenyl)-prop-2-en-1-one) by flow cytometry